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Re well-known molecular therapeutic agents. HSP90 inhibition results in a mechanismbased change in the expression of specific proteins [10]. In terms of the Akt/mTOR pathway, the inhibition of HSP90-Akt binding leads to the dephosphorylation and inactivation of Akt [3]. We postulated that an HSP90 inhibitor might be effective against UPS if an elevated expression of HSP90 is involved in the activa
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Re well-known molecular therapeutic agents. HSP90 inhibition results in a mechanismbased change in the expression of specific proteins [10]. In terms of the Akt/mTOR pathway, the inhibition of HSP90-Akt binding leads to the dephosphorylation and inactivation of Akt [3]. We postulated that an HSP90 inhibitor might be effective against UPS if an elevated expression of HSP90 is involved in the activa
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Y lavage fluid from these same children (86) (Fig. 12). Given that the extracellular GSH/GSSG and cysteine/CySS redox pools are under tight regulation during physiologic health (156, 157), these observations reflect a global disturbance in both thiol availability and thiol redox signaling in individuals with severe asthma that likely has important clinical and therapeutic implications. D. Glutathi
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Ked, `How do you think the fact that your child is a boy/girl affects the way you raise him/ her?' and children were asked, `Do you think the fact that you are a boy/girl affects the way in which your parents treat you?'). Data analysis Consistent with our critical interest in the ways in which gender is constructed and how these constructions promote or challenge gender inequitable relations, a F
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Of inequitable gender relations. More specifically, we use the term to refer to the way in which `widely shared gender stereotypes act as a ``common knowledge'' cultural frame that people use to begin the process of relating to one another and coordinating their interaction' (6, p. 2).Global Health Action 2016. # 2016 Rebecca Helman and Kopano Ratele. This is an Open Access article distributed und
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Of inequitable gender relations. More specifically, we use the term to refer to the way in which `widely shared gender stereotypes act as a ``common knowledge'' cultural frame that people use to begin the process of relating to one another and coordinating their interaction' (6, p. 2).Global Health Action 2016. # 2016 Rebecca Helman and Kopano Ratele. This is an Open Access article distributed und
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Than virus. This may be because the entailments of the virusThan virus. This may be because the entailments of the virus frame are less clear than the entailments of the beast frame, as people often talk about fighting viruses, infections, and disease (e.g., [3]). In several of the analyses below, we will report the results of two methods for coding the policies: one that is consistent with
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Of inequitable gender relations. More specifically, we use the term to refer to the way in which `widely shared gender stereotypes act as a ``common knowledge'' cultural frame that people use to begin the process of relating to one another and coordinating their interaction' (6, p. 2).Global Health Action 2016. # 2016 Rebecca Helman and Kopano Ratele. This is an Open Access article distributed und